Leptin Hormone

Leptin is a hormone made mainly within fat cells. Fat cells rapidly increase in size after a high-calorie meal. They also grow progressively with long-term excessive calorie intake, which in turn increases the release of leptin into the blood.

Leptin’s effect on the brain

Leptin communicates with the brain by telling it to slow down on energy consumption, for now, while the body has sufficient energy stored. It communicates satiety which in turn decreases fat storage and increases fat usage. It is also involved in increasing bone thickness and strength.

leptin hormone - regulation of appetite and metabolism

What is Leptin Resistance?

Through excessive eating and obesity and an increased number and size of fat cells, blood leptin levels rise very high. The brain over time becomes insensitive to the leptin hormone. At this point, leptin fails to decrease appetite as it should.  The stressed fat cells start to cause inflammation leading to an unhealthy storage of fat around and within internal abdominal organs, arteries and muscle white adipose tissue. This belly fat (Visceral Fat) is dangerous and can lead to the development of chronic diseases.  The effect of this leptin resistance results in increased blood pressure, insulin resistance, cardiovascular disease, cancers, osteoporosis and accelerated ageing.

By decreasing the blood leptin levels, leptin sensitivity returns, the healthy appetite – satiety messages resume, the desire to eat is then reduced, fat storage / usage returns to normal, and obesity is easier to control.

An optimal fasting leptin range is 3.7 – 7.4 ng/ml.

Leptin Hormone : Fast Facts

  • Discovery of Leptin: 1994
  • Where is Leptin produced: Fat cells
  • What is the function of Leptin: Leptin restores fat reserves as food is consumed. It is one of our bodies “survival” mechanisms that protects us against famine. Once fat reserves have been restored, Leptin then makes a decision on how much fuel the body is requiring and where it would be best utilised.

Why is it leptin such an important hormone to keep in balance?

Learn more about Muscle Nutrition

Fat Loss Peptides Leptin and how it communicates with the brain and fat tissue

Methods to reset leptin levels

There are natural methods to elevate leptin hormone levels which include fasting (24-72 hours), very low calorie diet of 500 calories per day, avoiding fructose, sugar, grains and processed foods. One should increase their protein consumption eating approximately (1 gram per kilogram of lean bodyweight per day) and consume healthy fats (coconut, coconut oil, avocados, butter, nuts, animal fats, krill oil), exercise, stress management. Testosterone decreases the leptin hormone, and estrogen increases it.
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