Heart Attack Treatment | Cardiac Repair and Regeneration
Heart Health News:
An alternative treatment, tested on mice has been discovered to instruct the heart to repair itself.
It was previously believed that damage caused by a heart attack would be permanentÂ and carried throughout life.
This study involving Thymosin beta 4 illustrates how the drug if used in advance of a heart attack, had the potential to “prime” the heart for repair.
By Staff Writers – News.com.au
A new study, reported in the journal Circulation, has discovered some alarming information regarding heart attacks. It revealsÂ almost half of heart attacks are âsilentâ. What this means is that alongside an increased threat of death, there were no visual signs indicative of a heart attack taking place. This does not lessen the harm or damage, the body experiences., rather it increases the overall risk to patients who are unaware they require treatment and lifestyle alterations.Â Hundreds of thousands of Australians may already be at risk, Â with the study finding that 45 per cent of heart attacks are silent. The co-author of the study, Dr Elsayed Soliman highlights an important point warningÂ âPatients donât know they have had a silent heart attack, they may not receive the treatment they need to prevent another one.âÂ The next attack is likely to cause a full cardiac arrest, which is usually fatal. Cardiovascular disease causesÂ 43,603 deaths in Australia (2013) working out to be 30 per cent of all deaths in that year.
- Shrivastava, S., Srivastava, D., Olson, E. N., DiMaio, J. M. and Bock-Marquette, I. (2010), Thymosin Î˛4 and cardiac repair. Annals of the New York Academy of Sciences, 1194: 87â96. doi: 10.1111/j.1749-6632.2010.05468.x
- Smart, N., Bollini, S., DubĂŠ, K. N., Vieira, J. M., Zhou, B., Riegler, J., Price, A. N., Lythgoe, M. F., Davidson, S., Yellon, D., Pu, W. T. and Riley, P. R. (2012), Myocardial regeneration: expanding the repertoire of thymosin Î˛4 in the ischemic heart. Annals of the New York Academy of Sciences, 1269: 92â101. doi: 10.1111/j.1749-6632.2012.06708.x
- Ildiko Bock-Marquette1,2,5,6, Ankur Saxena1,2,6, Michael D. White3, J. Michael DiMaio3 & Deepak Srivastava1,2,4 Thymosin Î˛4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Department of Pediatrics, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9148, USA.
- Kennedy-Lydon T, Rosenthal N. Cardiac regeneration: epicardial mediated repair. Proceedings of the Royal Society B: Biological Sciences. 2015;282(1821):20152147. doi:10.1098/rspb.2015.2147.
- Thymosin beta4 induces epicardium-derived neovascularization in the adult heart.
Paul R. Riley, Nicola Smart
Biochem Soc Trans. 2009 December; 37(Pt 6): 1218â1220. doi: 10.1042/BST0371218
- Ali, Shah R. et al. âExisting Cardiomyocytes Generate Cardiomyocytes at a Low Rate after Birth in Mice.â Proceedings of the National Academy of Sciences of the United States of America 111.24 (2014): 8850â8855. PMC. Web. 17 May 2016.
- Kirkham N, Murrells T, Melcher DH, Morrison EA. Diagonal earlobe creases and fatal cardiovascular disease: a necropsy study. British Heart Journal. 1989;61(4):361-364.
- Telltale visible signs of aging may predict heart disease âŚ (n.d.). Retrieved from http://newsroom.heart.org/news/telltale-visible-signs-of-aging-239569
- New report finds almost half of all heart attacks are âsilentâ . Retrieved fromÂ http://www.news.com.au/lifestyle/health/new-report-finds-almost-half-of-all-heart-attacks-are-silent/news-story/2f40956dc49fbe4a82a7931577d5fe38