Bodybuilding Peptides for Muscle Growth
Bodybuilding Peptides â€“ Triggering the Release of IGF-1 into the blood
One of GHâ€™s main effects, is to trigger the liver to produce and release insulin-like growth factor-1 (IGF-1) into the blood. GH also triggers IGF-1 production within cells. IGF-1 has primarily proliferative effects, which means it stimulates cell multiplication (hyperplasia) as well as an increase in the size of the cell (hypertrophy) (Adams 2002, Munteanu 2004, Zingg 2004).
Growth Hormone levels in the blood are controlled by a negative feedback mechanism. GH and IGF-1 levels in the blood inhibit GHRH release fromÂ the hypothalamus, increase SST release from the hypothalamus, and decrease GH release from the pituitary gland(Patrie 2004, Veldhuis 2001). These changes decrease GH production until blood levels decrease and the negative feedback is removed.
HIGH INTENSITY TRAINING AND ITS EFFECT ON MUSCLE GROWTH
Bodybuilding and weight training will stimulate more contractile protein. Contractile protein will then need further muscle nuclei (myonuclei) to function property. The inactive stem (or satellite) cells around the muscle fibre then has the ability to be stimulated to fuse with the muscle fibre. It can then differentiate into myonuclei, and help produce and support the additional contractile proteins. High intensity training is highly effective at both stimulating increased contractile protein, alongside supplying myonuclei to maintain cellular function. Maintaining the correct GH and testosterone levels also have the ability to do this.
GH LEVELS AND INCREASING MUSCULAR GROWTH
As we age, our growth hormone (somatopause) and testosterone (andropause in men) levels decline. While both increase briefly after exercise, growth hormone levelsÂ can be further elevated by bodybuilding peptides designed to stimulate GHÂ release from the anterior pituitary.
Bodybuilding peptides ordinarily fall into one of two categories.
- Growth Hormone StimulatingÂ Peptides
- Growth Hormone Releasing Peptides
Growth hormone has the additional benefit of stimulating connective tissue growth around the muscle (fascia, ligaments, tendons). This improves the connective tissueâ€™s recovery and repair after high-intensity training, and decreases the risk of overuse injury (tenosynovitis, tendinosis).